New regulations on pollutants and, specially, on CO2 emissions could restrict the use of the internal combustion engine in automotive applications. This paper presents a review of different technologies under development for meeting such regulations, ranging from new combustion concepts to advanced boosting methods and after-treatment systems. Many of them need an accurate control of the operating conditions and, in many cases, they impose demanding requirements at a system integration level. In this framework, engine control disciplines will be key for the implementation and development of the next generation engines, taking profit of recent advancements in models, methods and sensors. According to authors’ opinion, the internal combustion engine will still be the dominant technology in automotive applications for the next decades.