The purpose of the article is to evaluate the state of metabolic status of patients with distal onycholysis of hands. Materials and methods: Evaluation of hemoglobin, red blood cells, neutrophil granulocytes, the level of glycolytic processes of lactate and pyruvate, the activity of superoxide dismutase, catalase, myeloperoxidase, neutrophil elastase, serum alkaline phosphatase activity, as well as degradation products content of collagen structures to relative fractions of the blood free and peptide bound oxyproline. Results: It has been shown that free fraction oxyproline in 18 women with distal onycholysis of hands and hemoglobinemia prevails over peptide bound oxyproline fraction in blood, activated glycolytic processes on the modulation mechanism of adaptation with a slight increase of the lactate and pyruvate, the inhibition of activity of antioxidant enzymes, alkaline phosphatase and serum first phase elongation of blood coagulation as a result of the activated plasma recalcification time. Conclusion: The functional state of red blood cells, neutrophil granulocytes in the oppression of the first line of antioxidant enzyme defense and extension in patients with distal onycholysis of hands points to the formation of a mixed type of chronic hypoxia.