The aim of the present study was to evaluate tylosine efficacy administered by intramuscular for treatment of cryptosporidiosis in naturally infected goat kids. These animals were randomly assigned to test group (n=10) and control (n=10) group after routine clinical examination. All kids showed mild mental depression, decrease in suckling reflex and diarrhea in different severity. Fecal samples were analyzed via virological, bacteriological and coccidial examinations. The consistency of feces was assessed as pastose, semiliquid, or liquid. The rates of infection of the samples were evaluated semi-quantitatively. Tylosine was given by intramuscular route to test group - 2 at a dosage of 10 mg/kg of body weight, twice a day for 5 days. However, isotonic saline solution (1.0 ml) was used by intramuscular route to the control group, once a day for 5 days. Hematological results of all the kids were within normal limits except for hematocrit rates which were mild high in 15 kids as a result of dehydration. However, OPG was not detected in both of group after treatment. It was suggests that tylosine applied animals has been shown more rapid recovery than control group. Tylosine may be useful in order to reduce of treatment period in the disease. In future, more detailed studies which evaluate the effects of tylosine in goat kids with cryptosporidiosis are needed.