Background: S. aureus is one of the most pathogenic bacteria. Lastly, increasing of resistance, led to difficulty in treatment, specially Resistance to methicillin, limited treatment of infections by S.aureus. Because of these, we evaluated the drug Resistance and Staphylococcal cassette chromosome (SCCmec) types among methicillin-Resistant Staphylococcus aureus (MRSA), in this study. Methods: In a cross- sectional study, we collect S.aureus isolates and then evaluate them with diagnostic tests such as drug susceptibility, MIC, molecular genotyping of SCCmec, to recognition of drug resistance in isolates. Results: 78isolates among totally 164 isolates were MRSA. There is no resistance to vancomycin, but almost, there is high resistance about another antibiotics. Type II were mostly frequent type, type IV were less among another types. Conclusion: In compare with another researches we can recognized increasing of resistance in S. aureus, because of using high level antibiotics in infections treatment.