Satellite altimetry is a key component of the global observing system and plays a major role in the study of the mesoscale processes that drive most of the ocean circulation variability at middle and high latitudes. However, satellite altimetry alone provides only surface information at a limited spatio-temporal resolution. To address these limitations and to better describe the mesoscale three-dimensional variability, it is necessary to complement altimetry data with additional remote and in situ measurements. This study provides an update of the recent advances in the study of the mesoscale variability using a combination of altimetry and other independent observations, with an emphasis on the results obtained for the western Mediterranean Sea. The circulation in this area is complex because of the presence of multiple interacting scales, including basin-scale, sub-basin–scale and mesoscale structures. Thus, characterizing these processes requires high-resolution observations and multi-sensor approaches. Accordingly, multi-platform experiments and analyses have been designed and undertaken in the different sub-basins of the western Mediterranean Sea. These studies have demonstrated the advantages of synergetic approaches that use a combination of observation techniques and are able to resolve different spatio-temporal scales with the aim of better understanding mesoscale dynamics.