Objective: To analyze the vaccine schedule for preterm infants in a program of special immunobiologicals. Methods: A documental study conducted at a Reference Center of Special Immunobiologicals (CREATE) situated in a general hospital of tertiary care in pediatrics. The sample consisted of 112 newborns with gestational age below 37 weeks and weighing less than 2500g, suitable for vaccination, assisted in 2006-2007. Data collection was done from registration forms, reference records and registers of control of special immunobiologicals’ administration, in year 2008. Results: The results showed that 22 (20%) newborns were weighing between 1000 and 1499g. Regarding gestational age, 39 (35%) were born between 30 and 34 weeks of pregnancy. Most proceeded from public institutions, 37 (69%). The vaccination schedule of most children, 68 (61%), was incomplete. The main clinical indications for special immunobiologicals were prematurity and bronchopulmonary dysplasia. It was observed that 89% (n = 100) of preterm infants received the pneumococcal vaccine (Prevenar). For preterm infants who were at risk of developing serious events related to the tetravalent vaccine, it was elected the scheme Prevenar + DTPa + Hib. Simultaneous administration of meningococcal conjugate vaccines - C (MncC) with Prevenar was indicated for candidates for cochlear implants. Conclusion: The integral care to the preterm newborn involves early immunization, that is, the one that starts in the neonatal unit, and requires the inclusion of special immunobiologicals, which should be criteriously recommended.