synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-plasmodium falciparum agents
Abstract
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.
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203407
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203407
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10.3390/molecules19022166
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Scimatic Chain (ID: 481)
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