The motion of single air bubbles in flat channels is experimentally investigated. The electrodiffusion technique of near-wall flow diagnostics is applied to measure the wall shear stress distribution under large rising bubbles. The measurements are synchronized with the visual observation of bubble movement by a high-speed camera. The analysis of video records provides information on the bubble shape and terminal velocity. The experiments are carried out for three different channel configuration (with heights of 1.5, 4, and 8 mm), cover a wide range of channel inclination angles (from horizontal to vertical position), and dealing with both the bubbles in stagnant and in co-flowing water. The directionally sensitive, two-strip electrodiffusion probe is proved to be an effective tool to investigate the near-wall flow response to translating bubbles. It provides information not only on the wall shear rate distribution, but also detects the location of near-wall flow reversal, gives an estimate of the thickness of liquid film separating the large bubble from the wall, and provides also the characteristics of capillary waves appearing in the bubble tail region. The effect of channel inclination angle on the modification of wall shear stress distribution along the upper and bottom wall is also discussed.