L., (chicory) is employed in various traditional medicines to treat a wide range of diseases and disorders. In the current investigation, two new naphthalane derivatives viz., cichorins D () and E (), along with one new anthraquinone cichorin F (), were isolated from In addition, three previously reported compounds viz., β-sitosterol (), β-sitosterol β-glucopyranoside (), and stigmasterol () were also isolated from Their structures were established via extensive spectroscopic data, including 1D (H and C) and 2D NMR (COSY, HSQC and HMBC), and ESIMS. Cichorin E () has a weak cytotoxic effect on breast cancer cells (MDA-MB-468: IC: 85.9 µM) and Ewing's sarcoma cells (SK-N-MC: IC: 71.1 µM); cichorin F () also illustrated weak cytotoxic effects on breast cancer cells (MDA-MB-468: IC: 41.0 µM and MDA-MB-231: IC: 45.6 µM), and SK-N-MC cells (IC: 71.9 µM). Moreover compounds - did not show any promising anthelmintic effects.