Soybean in Colombia is constituted, like corn, as the main raw material for the production of balanced concentrates for animal feeding. The national soybean production satisfies only 7.0% of the demand for poultry-swine chain, with imports in 2014 of 363501 tons of grain and 1018256 tons of soybean meal. Currently, in Colombia, soybean is only produced in the Orinoquia region, mainly in the high plains and foothills and is part of the rice-corn-soy rotation system for the colonization of native savannas. In order to promote cultivation which allows the occupation of 500000 potentially hectares in the foothills with new varieties beyond current and meet domestic demand, Corpoica is responsible for the plant breeding. As a result of a research in plant genetic resources during nine years (2006-2014), the study of a group of elite soybean genotypes on two contrasting regions: high plains and foothills. In addition, main components analysis per genotype-location interaction were determined for L-189 genotype identified with specific adaptation to the foothills and the highest experimental yield of 2660 k.ha-1, superior in more than half a ton to the yield obtained by the control varieties (P-34 and Superior 6); with traits which bring competitive advantages such as a larger number of pods per plant (56) and smaller seeds (15.2g), besides an acquired tolerance to the Cercospora sp. pathogen.