Energy of nodes is an important factor that affects the performance of Wireless Sensor Networks (WSNs), especially in the case of existing selfish nodes, which attracted many researchers’ attention recently. In this paper, we present a reputation-based uneven clustering routing protocol (R-bUCRP) considering both energy saving and reputation assessment. In the cluster establishment phase, we adopt an uneven clustering mechanism which controls the competitive scope of cluster head candidates to save the energy of WSNs. In the cluster heads election phase, the residual energy and reputation value are used as the indexes to select the optimal cluster head, where the reputation mechanism is introduced to support reputation assessment. Simulation results show that the proposed R-bUCRP can save node energy consumption, balance network energy distribution, and prolong network lifetime.