In recent years 3D printing technology is developing rapidly. In the foreseeable future, when 3D printing is widely used, the world’s industrial structure will be greatly changed. Based on the actual data, this paper constructs an international supply chain model using system dynamics method. And it simulates the reconstruction trend of the supply chain after 3D printing application. The conclusion shows that the universal application of 3D printing will lead to the worldwide transport volume shrinking dramatically. The manufacturing activities will gradually outflow to the countries which are closer to the final customers. The relevant countries should carry out feasible measures to face this opportunity and challenge. The measures include the reform of logistics facilities, the logistics cooperation with the origin of 3D printing materials, and the matched transportation of 3D printing materials and traditional processing ones.