rituximab for the treatment of patients with autoimmune hepatitis who are refractory or intolerant to standard therapy
;Kelly W Burak;Mark G Swain;Tania Santodomino-Garzon;Samuel S Lee;Stefan J Urbanski;Alexander I Aspinall;Carla S Coffin;Robert P Myers
indian journal of pharmacology2013Vol. 27pp. 273-280
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burak2013canadianrituximab
Abstract
BACKGROUND: Although most patients with autoimmune hepatitis (AIH) respond to treatment with prednisone and/or azathioprine, some patients are intolerant or refractory to standard therapy. Rituximab is an anti-CD20 monoclonal antibody that depletes B cells and has demonstrated efficacy in other autoimmune conditions.