In this paper, the authors analyze the results of the survey 29 adolescent boys with different mass lesions of the hypothalamic-pituitary region. It is established a variety of disorders of growth and development, such as growth retardation (20.6 %), delayed growth and puberty (20.6 %), true precocious puberty (13.8 %), etc. The most commonly encountered patients with inactive pituitary adenoma — 11 cases out of 29 (37.9 %). The most frequently delayed physical and sexual development was observed in patients with inactive pituitary adenoma — in 6 cases (20.6 %).