Objective: The aim of present study was the prediction of tendency to substance abuse on the basis of self esteem and components of emotional intelligence. Method: In this descriptive-correlational Study our sample included 153 students of Azad university of qorveh which selected by simple random sampling. APS, Rosenberg’s self esteem scale and Bradberry’s emotional intelligence questionnaires administered among selected sample. Results: Research findings represented that there are negative significant correlation between tendency to substance abuse and self esteem, also between tendency to substance abuse and self management and relationship management. Conclusion: Results of this study are showing the predictor role of self esteem, self-management and relationship management in tendency to substance abuse.