synthesis of pyrrolo[2,1-a]isoquinolines by multicomponent 1,3-dipolar cycloaddition

synthesis of pyrrolo[2,1-a]isoquinolines by multicomponent 1,3-dipolar cycloaddition

;Marcel Mirel Popa;Denisa Dumitrescu;Emilian Georgescu;Florentina Georgescu;Florea Dumitrascu
Journal of ethnopharmacology 2013 Vol. 18 pp. 2635-2645
162
popa2013moleculessynthesis

Abstract

Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy.

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