Surgical site infection (SSI) remains a complication of spine deformity surgery. While fusion/instrumentation failure in the setting of SSI has been reported, few studies have investigated the relationship between these entities. We examine the relationship between early SSI and fusion/instrumentation failure following instrumented fusion in patients with thoracolumbar scoliosis.A retrospective review of a prospectively maintained case series for patients undergoing spine surgery between 1/1/2006 and 10/3/2017. Inclusion criteria included age ≥18 years and surgery performed for correction of thoracolumbar scoliosis. Data collected included various demographic, clinical, and operative variables.532 patients met inclusion criteria with20 (4%) experiencing SSI. Diabetes mellitus was the only demographic risk factor for increased SSI (p=0.026).Number of fused levels, blood volume loss and operative time were similar between groups. Fusion/instrumentation failure occurred in 68 (13%) patients, 10 of whom (15%) had SSI, while of the 464 patients with no fusion/instrumentation failure, only 10 (2%) had SSI (p<0.001). Of the 20 patients with SSI, 10 (50%) had fusion/instrumentation failure, while in the 512 patients with no infection, only 58 (11%) had fusion/instrumentation failure (p<0.001). Patients with infection also experienced significantly shorter time to fusion/instrumentation failure (p=0.025), higher need for revision surgery (p<0.001), and shorter time to revision surgery (p=0.012).Early SSI significantly increases the risk of fusion/instrumentation failure in patients with thoracolumbar scoliotic deformity, and significantly shortens the time to failure. Patients with early SSI have a significantly higher likelihood of requiring a revision surgery, and after a significantly shorter time interval.