: This paper analyzes the specialization pattern of international trade in the state of Santa Catarina, identifying the most dynamic productive sectors, between the years of 1999 and 2014. In order to do this, it was calculated indicators such as the Revealed Symmetric Comparative Advantage index (RSCA), the Intra-industry Trade Index (IIT), the indicator of Export Concentration and the Imports coverage rate. The results indicated that despite the fact that the state aims to strive for diversification of the productive sector and of the export portfolio, it remains predominantly comprised of sectors based on agro-industrial activities; such as food, tobacco and beverages; and timber. Therefore, it is possible to infer that the sectors specialized in international trade are those with conventional comparative advantages, although it was detected the existence of Intra-industry trade in the sectors of machinery and equipments. Keywords: Exports. Comparative advantage. Santa Catarina.