The utility of biomarkers for the action of endothelium and epithelium of the pulmonary microvasculars is unknown and their action of being barrier for edema and dysfunction of them cause ARDS and its mortality rate with no specific drugs efficiency is high (1).

Recently, there are many important information about biomarkers in ARDS (2). These biomarkers in ARDS can effect either cellular activation or cell injury. Currently, biomarkers are the most important research tool. The biomarkers have an important role in ARDS treatment in the function.

There is an executive phase with some damage like edema and necroses. Then, fibro-proliferative phase will be happen. To understand the mechanism of repair, we focus on the function of alveolar type I (3).