Antitick plants and related ethnoknowledge/ethnopractices with potential for integrated tick control and management strategies to improve livestock production are reviewed. About 231 plants reviewed showed a variety of bioactive properties, namely, being toxic, repellent, antifeedant, and antiovipositant and ability to immobilize target tick species. These ethnobotanical substances are potentially useful in developing sustainable, efficient, and effective antitick agents suitable for rural livestock farmers. Majority of these plants are holistic in action, economically affordable, user friendly, easily adaptable and accessible, and environmentally friendly and help develop community-driven tick control interventions well suited to local conditions and specific to different livestock communities. Such a multipurpose intervention best fits the recent ascendancy of individual livestock owners as the key players in tick control programmes, particularly following the withdrawal of subsidies accorded to tick control programmes by most African government agencies since mid-1980s. However, scientific validation of antitick ethnobotanicals on their efficacy and formulation of packages easily handled by local communities is necessary to achieve a significantly increased use of such remedies. It is envisaged that the results of validation may lead to the discovery of effective and affordable antitick products. The effectiveness of these “best bets” ethnopractices can be greatest, if they are appropriately blended with conventional technologies.