We present a review with the objective of integrate, describe and analyze the current state of knowledge generated about zoonotic diseases in the Yucatan Peninsula in order to establish a theoretical and methodological framework for the approach of a multidisciplinary research proposal that meets current problems and leading to the search and generation of epidemiological surveillance and measures to prevent these diseases. Although the information collected is limited to the regional level, the prospects for study that arise in this document are applicable to different scales and geographic regions