This study was conducted to generate baseline information on the nutritional composition, mineral content and antinutritional factors of three capsicum varieties (Marako fana, Bako local and Oda haro) grown in Ethiopia. In relation to proximate composition, Marako fana, Bako local and Oda haro contained 9.2, 9.0 and 8.8% moisture; 11.9, 8.8 and 9.2% crude protein; 27.3, 26.0 and 28.6% crude fiber and 11.2, 9.5 and 9.2% fat (oleoresin) on wet weight basis. They also contained 1.7, 1.6 and 1.8 mg/100 g potassium; 27.2, 38.2 and 54.6 mg/100 g calcium and 7.2, 6.9 and 9.6 mg/100 g iron on wet weight basis. Tannin was found to be 0.142, 0.164 and 0.148 mg/100 g, respectively, while phytate was not detected in any of the samples. Analysis of variance and LSD (least significant difference) test revealed that protein and oleoresin of Marako fana were significantly higher (p<0.05) than Bako local and Oda haro. Potassium, calcium and iron contents of Oda haro were significantly higher (p<0.05). Based on these results Marako fana is preferable for large scale production of oleoresin, while Oda haro is nutritionally preferable because it contains high amounts of potassium, calcium and iron.