The World Health Organization estimates that approximately 400.000 new cases of Leishmaniasis occur worldwide each year. Cutaneous Leishmaniasis is an endemic disease in Iran. CL is caused by several species of Leishmania. Physical and Chemical Modalities have been used to treatment of cutaneous Leishmaniasis. Cryotherapy is a physical and interalesional glucantime is a chemical modality. In this study cryotherapy and interalesional glucantime were compared. In the first group 35 patients treated with cryotherapy. 91.4% had complete cure both clinical and parasitological. In the second group 30 patients treated with interalesional glucantime. 63.33% had complete cure both clinical and parasitological. Results: Our study show that cryotherapy is better than interalesional glucantime in treatment of CL (P=0.003). Further studies are recommended