This paper attempts to answer the question of whether or not “segregation”, or at least “differentiation”, takes place in commercial areas in terms of “spatial homophily”. Based on the 2010 Household Travel Survey data in the Seoul metropolitan area, we first identify Seoul’s top 20 destinations for weekend shopping and leisure trips. Then, using traveler information regarding gender, age, and income, we calculate the percentage of female visitors, as well as the average and the coefficient of variation of age and income, for each destination. These statistics are employed to identify which groups and which shopping and leisure activity centers are characterized distinctively by spatial homophily. As a result, it is proved that “differentiation” takes place in commercial areas in terms of “spatial homophily”. Moreover, paying attention to the “Old Age, Low Income” cluster in the old downtown area, we can raise the possibility of “segregation” in commercial areas.