Multiphase flow, including submicron and nano-particles simultaneously, around circular cylinder is studied experimentally in this paper, with Reynolds number in the range of 5200 to 35000. The results show that as Re increasing, flow characteristics hardly influence particles larger than 60.4 nm. For Re = 9000 and 16000, despite of the particles deposition, the concentration of bigger particles ranged from 220.7 nm to 523.3 nm in the wake is obviously higher than that at the free stream, whereas both is close to each other for smaller particles.