This work proposes a novel adaptive type 2 fuzzy sliding controller (AT2FC) for vibration control of magnetorheological damper- (MRD-) based railway suspensions subjected to uncertainty and disturbance (UAD). The AT2FC is constituted of four main parts. The first one is a sliding mode controller (SMC) for specifying the main damping force supporting the suspension. This controller is designed via Lyapunov stability theory. The second one is an interpolation model based on an interval type 2 fuzzy logic system for determination of optimal parameters of the SMC. The third one is a nonlinear UAD observer to compensate for external disturbances. The fourth one is an inverse MRD model (T2F-I-MRD) for specifying the input current. In the operating process, an adaptively optimal structure deriving from the SMC is created (called the Ad-op-SMC) to adapt to the real status. Working as an actuator, the input current for MRD is then determined by the T2F-I-MRD to generate the required damping force which is estimated by the Ad-op-SMC and the nonlinear observer. It is shown that the obtained survey results reflect the AT2FC’s excellent vibration control performance compared with the other controllers.