The problems of the innovation and investment activity in the industrial sphere at the regional level are regarded in the article The problems are regarded on the basis of the optimum employment of all elements factors and mechanisms including them into whole contour of technological structure integration modes and modernized techniques machines systems and active productive potential and power modern basic innovations The integral criteria were formulated They help to evaluate inter-branch differentiation of the efficacy of the manufacturing factors use and its impact on the economical effectiveness of the whole industry The methodical prove of the rational use of different types of the technical progress in the industrial sub-brunches of the region are presented.