Objective: We aimed to evaluate the efficacy of the percutaneous nephrostomy (PN) performed by using combined ultrasonography (USG) and fluoroscopy. Methods: Eighty-seven patients (48 female, 39 male; mean age, 58.2; range, 19-91) who underwent 106 PN procedures performed by using USG and fluoroscopy combination between July 2011 and May 2015 were retrospectively analyzed. The technical success was considered if nephrostomy catheter was placed within renal pelvis and functioned spontaneously. All patients received preprocedural prophylactic antibiotic and preprocedural coagulation parameters and platelet count were tested in all patients routinely. The procedural complications are classified as major, minor and catheter-related. The technical success rates and complication rates of the PN procedure were calculated. Results: PN was performed for benign causes in 47 patients (54%) and for malignant causes in 40 patients (46%). A total of 106 nephrostomies were performed in 101 kidneys (95.1%) with dilated systems and in 5 kidneys (4.9%) with non-dilated systems. The technical success rate of PN was 98.1% (104/106 PN procedures). Major complication was not observed in any patients. Transient hematuria as a minor complication was seen in 11 patients (12.6%). Catheter dislodgement occurred in 11 patients (12.6%). Conclusion: The PN performed by using combined USG and fluoroscopy is effective and reliable procedure in urinary decompression and diversion with high success and low complication rates. J Clin Exp Invest 2015; 6 (2): 170-174