This paper aims at showing the heuristic value of several semiotic models in scientific research, and in particular the neurosciences. In Greimas and Lotman’s theories, for example, we find effective and operationalized instruments that could help us address some of the most difficult problems related to the mind, consciousness, and the origin of semiosis and languages. In this way, certain scientific discoveries in the neurosciences seem to gain coherence in the light of complex systems theories and integrated information models. The emerging concept is a view of “extended mind” in which human consciousness requires an inter-subjective mode for its construction and functioning.