This article describes and analyzes the “Ponto de Encontro e Cultura - PEC”, an experience developed by METUIA - University of São Paulo (USP-SP) in São Paulo from 2007 to 2011 which linked occupational therapy to areas of cultural production. It was attended by the homeless, occupational therapists and students of occupational therapy. To perform the analysis of the different dimensions of the experience we were guided by the meaning-space notion. We took the space as an organizer to understand a reality in which relationships and actions are being empowered in four different spheres: culture, economics, politics and knowledge. We noted that this practice showed that there was an ongoing collective effort to build what may be called piece. This characterizes a process where the space is a common reference point which brings into play different modes of sociability that are created by the management of common symbols and codes. It was important to recognize and appreciate the plurality of modes of knowledge. Thus, we observed that, from the cultural sphere, it is possible to articulate economics, health, social assistance, politics, and knowledge production.