Abstract
BACKGROUND
The aim of the study is to study the clinical profile of diabetic ketoacidosis in children with type 1 diabetes to identify the
precipitating factors, to assess the metabolic alterations due to this illness and to correlate these parameters with the outcome.
MATERIALS AND METHODS
This was a prospective observational study and 33 children admitted in PICU during the study period were recruited for the
study.
RESULTS
24 children were newly-diagnosed cases and 9 children were already established cases of type 1 diabetes. Mean age group was
10.7 years. Major precipitating causes of DKA in established cases were intercurrent respiratory infections and omission of
insulin. Nausea, vomiting, thirst and polyuria were the most common symptoms. Mean duration of symptoms before diagnosing
DKA were 20 days in newly-diagnosed cases and 4 days in established cases. ¾ of children had dehydration at the time of
admission. Severity was more in younger children. Commonest biochemical abnormality was hypokalaemia. Late diagnosis and
delay in the initiation of treatment were the commonest predisposing factors for the development of cerebral oedema.
CONCLUSION
DKA is a life-threatening complication of type 1 diabetes and the red flag signs of bad outcome were young age, late diagnosis,
late referral and late initiation of treatment. Hence, a high index of suspicion is necessary to diagnose DKA in first presentation
of diabetes as well as in established cases.
Citation
ID:
154592
Ref Key:
kumar2017journalprecipitating