This article traces the career of Thomas Adeoye Lambo, the first European-trained psychiatrist of indigenous Nigerian (Yoruba) background and one of the key contributors to the international development of transcultural psychiatry from the 1950s to the 1980s. The focus on Lambo provides some political, cultural and geographical balance to the broader history of transcultural psychiatry by emphasizing the contributions to transcultural psychiatric knowledge that have emerged from a particular non-western context. At the same time, an examination of Lambo's legacy allows historians to see the limitations of transcultural psychiatry's influence over time. Ultimately, this article concludes that the history of transcultural psychiatry might have more to tell us about the politics of the 'transcultural' than the practice of 'psychiatry' in post-colonial contexts.