The article resolves of actual problem of interrelation of clinical and endoscopic aspects of mucosal candidosis in upper part of digestive tract. The results of investigation performed in 122 patients led to reveal the prevalence of dyspeptic syndrome in patients with this pathology, in patients with esophageal disorder the intensity of abdominal pain syndrome was 1.5 times higher than in group with only oropharyngeal candidosis (p < 0.001). The deeper mucosal disorder by Candida was associated with increase of frequency of revealing macroscopic signs of esophageal inflammation (р < 0.05), fur (r = 0.220; р = 0.02), difficulty of food pass through the esophagus (r = 0.235; р = 0.02), retrosternal pain (r = 0.249; р = 0.01) with absence of influence of such inflammatory factors as gastroesophageal and duodenogastral refluxes. There was revealed the direct relation of macroscopic signs of inflammation and postulcerative deformation in duodenal bulb with mucosal candidosis degree (r = 0.250; р = 0.01). On the whole the analysis of received data showed the necessity of further study of the role of opportunistic infection in formation pathological process and development of diseases.