The variational multiscale element free Galerkin method is extended to simulate the Stokes flow problems in a circular cavity as an irregular geometry. The method is combined with Hughes’s variational multiscale formulation and element free Galerkin method; thus it inherits the advantages of variational multiscale and meshless methods. Meanwhile, a simple technique is adopted to impose the essential boundary conditions which makes it easy to solve problems with complex area. Finally, two examples are solved and good results are obtained as compared with solutions of analytical and numerical methods, which demonstrates that the proposed method is an attractive approach for solving incompressible fluid flow problems in terms of accuracy and stability, even for complex irregular boundaries.