Perceived causes, diagnosis and treatment of redwater (babesiosis) and gallsickness (anaplasmosis) in cattle by livestock farmers in communal areas of the central Eastern Cape Province were investigated by means of participatory methods, semi-structured interviews and a questionnaire survey. Most livestock owners relate the causes of these diseases to excessive grazing of lush green grass, which is thought to bring about an accumulation of bile in the body. The majority of livestock owners diagnose gallsickness and redwater on the basis of presenting signs and post mortem findings. Eighty nine percent of a total of 343 livestock owners participating in the study claimed to administer herbal remedies to treat the 2 tick-borne diseases; 75 % of these combine herbal remedies with conventional medicines and 25 % use herbal remedies only. Application of herbal remedies was reportedly aimed mainly at the removal of excess bile. However, some plant species used to prepare herbal remedies are reported to possess activities ranging from anti-inflammatory, analgesic, antimicrobial, anti-pyretic and purgative, and may be effective in the treatment of gallsickness and redwater. A lack of understanding of the causes and transmission of gallsickness and redwater, leading to ill-directed treatment, and widespread deviation from the directions of use when administering conventional medicines, were identified as problems that could be addressed by farmer training and the supply of appropriate information.