Relevance. The distribution of patients of the oncohematological department according to the main nosological units reflecting the main hematological diseases of the elderly and senile patients, Hodgkin's lymphoma young patients of and HIV-infected patients of the hematologic profile is shown. These indicators are necessary for statistical processing and profile for doctors of the city and the country. Aim. There are shown diagnostic methods and treatment programs for major hematological diseases of elderly and senile patients, young patients with Hodgkin's lymphoma and HIV-infected patients with hematological malignancies. Materials and methods. Data on 535 persons entered the department 1351 times are summarized. Mortality was 6.1%. Results. Hospitalized: acute leukemias - 22 patients, chronic myeloproliferative diseases - 61, myelodysplastic syndrome - 42, chronic lymphoproliferative diseases - 63, anemia - 22, others - 38 HIV-infected - 45 patients. Conclusion. These nosologies reflect the structure of hematological diseases in the population of elderly and senile patients, the frequency of Hodgkin's lymphoma and the composition of HIV-infected patients. Diagnosis and therapy were carried out in accordance with generally accepted programs with achievement of average results of treatment. Young patients with HIV infection in the stage of secondary diseases suffered mainly from aggressive lymphomas with effective treatment of about 50%.