Occlusal splints are a standard method to treat disc displacement with reduction of the temporomandibular joint (TMJ). They can be classified into three major groups on the basis of function: stabilization splints, distraction splints (pivot), and anterior repositioning splints. The aim of this paper is to introduce a modified mandibular splint, the Kaohsuing Medical University splint, and its associated treatment regimen for management of disc displacement with reduction of the TMJ. The key points for fabrication of the KMU splint include the occlusal surface of the mandibular splint must be indented and average bite elevation 1.5 mm vertically. The patient should wear it 24 hours a day for the first 4 weeks, then wear it while eating and sleeping for the next 2 weeks, and wear it only while sleeping for the last 2 weeks. Patients must understand that the success of treatment depends on their compliance with the regimen.