lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
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lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

;Maria Gutierrez-Arcelus;Nikola Teslovich;Alex R. Mola;Rafael B. Polidoro;Aparna Nathan;Hyun Kim;Susan Hannes;Kamil Slowikowski;Gerald F. M. Watts;Ilya Korsunsky;Michael B. Brenner;Soumya Raychaudhuri;Patrick J. Brennan
educacao e sociedade 2019 Vol. 10 pp. 1-15
156
gutierrez-arcelus2019naturelymphocyte

Abstract

Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with changes in proliferation and effector functions.

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DOI:
10.1038/s41467-019-08604-4
URL:
http://link.springer.com/article/10.1038/s41467-01...

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ID: 144540
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