secreted metalloproteases adamts9 and adamts20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
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secreted metalloproteases adamts9 and adamts20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

;Sumeda Nandadasa;Caroline M. Kraft;Lauren W. Wang;Anna O’Donnell;Rushabh Patel;Heon Yung Gee;Kay Grobe;Timothy C. Cox;Friedhelm Hildebrandt;Suneel S. Apte
educacao e sociedade 2019 Vol. 10 pp. 1-19
205
nandadasa2019naturesecreted

Abstract

Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique periciliary vesicles with proteolytic activity.

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DOI:
10.1038/s41467-019-08520-7
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http://link.springer.com/article/10.1038/s41467-01...

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