Background: We report a rare case of acute eosinophilic pneumonia (AEP) associated with heated rubber fume exposure. Methods: A 31-year-old Ethiopian man, working at a rubber plant, was admitted to our hospital because of refractory dyspnea and fever. Computed tomography of the chest showed bilateral interstitial shadows and pleural effusion. We suspected AEP and performed fiberoptic bronchoscopy. Results: The eosinophil fraction was elevated at 59% in the bronchoalveolar lavage fluid (BALF). From the history of inhalation of heated rubber at the working place and hypereosinophilic counts in the BALF, he was given a diagnosis of AEP associated with heated rubber fume exposure. His symptoms and chest radiographic findings were drastically improved by corticosteroid therapy. Conclusions: Heated rubber fume can be a causative substance for AEP. In similar situations, physicians should consider AEP and order various examinations for confirmation.