Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
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Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis

Lee, Ji-Eun;Park, Young-Kwon;Park, Sarah;Jang, Younghoon;Waring, Nicholas;Dey, Anup;Ozato, Keiko;Lai, Binbin;Peng, Weiqun;Ge, Kai;
Nature communications 2017 Vol. 8 pp. 1-12
233
lee2017brd4nature

Abstract

Despite being an important cancer drug target, the role of epigenetic reader Brd4 in cell differentiation and development remains unclear. Here, the authors provide evidence that Brd4 plays an important role in adipogenesis and myogenesis by binding to active enhancers to regulate gene expression.

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