Aim: This study aimed to comparatively analyze, under scanning electron microscope (SEM), the effect of the use of QMix® and SofScale™ as an adjunct to scaling and root planing (SRP) on periodontally compromised root surfaces. Settings and Design: This study was carried out in K. M. Shah Dental College and Hospital, Vadodara. Methodology: This was a single-blinded in vitro study which compared QMix® and SofScale™ as an adjunct to SRP on periodontally compromised root surfaces under SEM. Statistical Analysis Used: Statistical analysis was done using a nonparametric Mann–Whitney U-test to test the null hypothesis that there is no difference between the test and control groups. Results: The sum of ranks for QMix® was 306.50 and the sum of ranks for SofScale™ was 513.50. The group which was treated with QMix® showed statistically significant results (P = 0.004) as compared to group which was treated with SofScale™.Conclusion: Comparative analysis showed that QMix® had significantly better smear layer removal ability as compared to SofScale™. However, uniform root surface was achieved with both QMix® and SofScale™.