The problems of regional industrial complex development on the basis of cluster approach are observed in the article. The methodics of estimation of regional industrial complex development is carried out, which enables to study it as the mediation system of specific, territorial and scientific-innovation functioning aspects. The authors' typology of regional industrial clusters is described, where priorities for study are marked. The authors' approach of methodical explanation of industrial clusters priorities forming as the basic elements of regional industrial complex development is represented. Business models of different types functioning clusters are shown.