subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
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subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

;Carine Z. J. Lim;Yan Zhang;Yu Chen;Haitao Zhao;Mary C. Stephenson;Nicholas R. Y. Ho;Yuan Chen;Jaehoon Chung;Anthonin Reilhac;Tze Ping Loh;Christopher L. H. Chen;Huilin Shao
educacao e sociedade 2019 Vol. 10 pp. 1-11
140
lim2019naturesubtyping

Abstract

Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity.

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DOI:
10.1038/s41467-019-09030-2
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http://link.springer.com/article/10.1038/s41467-01...

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