This paper presents an experimental study undertaken to investigate the seismic behavior of full scale square (300 mm × 300 mm) reinforced concrete (RC) columns strengthened with novel systems employing carbon fiber-reinforced polymers (CFRP) wraps. Experimental tests were carried out by subjecting specimens to a constant axial load and a cyclically reversed horizontal force applied in displacement control. Results have allowed for investigating the influence of the used strengthening systems on the specimens’ performance in terms of flexural strength and ductility as well as on the exhibited failure modes. The effectiveness of the studied techniques is also evaluated by comparing the performance of tested specimens with that of companion columns strengthened with alternative CFRP systems investigated in a previous experimental campaign.