The presence and persistence of an 18-day quasi-periodic oscillation in the ionospheric electron density variations were studied. The data of lower ionosphere (radio-wave absorption at equivalent frequency near 1 MHz), middle and upper ionosphere (critical frequencies f₀E and f₀F2) for the period 1970–1990 have been used in the analysis. Also, solar and geomagnetic activity data (the sunspot numbers Rz and solar radio flux F10.7 cm, and a_N index respectively) were used to compare the time variations of the ionospheric with the solar and geomagnetic activity data. Periodogram, complex demodulation, auto- and cross-correlation analysis have been used. It was found that 18-day quasi-periodic oscillation exists and persists in the temporal variations of the ionospheric parameters under study with high level of correlation and mean period of 18–19 days. The time variation of the amplitude of the 18-day quasi-periodic oscillation in the ionosphere seems to be modulated by the long-term solar cycle variations. Such oscillations exist in some solar and geomagnetic parameters and in the planetary wave activity of the middle atmosphere. The high similarities in the amplitude modulation, long-term amplitude variation, period range between the oscillation of investigated parameters and the global activity of oscillation suggests a possible solar influence on the 18-day quasi-periodic oscillation in the ionosphere.