Developing innovation, based on knowledge and technology, as a driving force of the economy, is necessary for survival and is required in having strong interactions within the globalized world of business. Innovation and technology development require an intertwined network of organizational interactions between public and private sector. The activities and interactions of these firms are the reasons for innovation development in the framework of innovation systems. Following strategies is of crucial necessity and importance in industries such as aerospace and remotely-piloted helicopters (RPH) with their complex characteristics, costly and time-consuming processes. Understanding the business environment and identifying the success factors is a significant step towards adopting innovative strategies and planning for technology development. The aim of this article is to evaluate the key success factors in technological innovation development of remotely-piloted helicopters (RPH) industry. The methodology used in this article is Best-Worst method which is considered as one of the most prominent and effective MCDM methods. Based on a case study and by reviewing the extant and relevant literature, the key success factors of technological innovation development of remotely-piloted helicopters (RPH) industry in Iran were identified. Then by applying the “Best-Worst” method and the experts’ opinions, the key success factors were analyzed and prioritized. Finally, some suggestions are made by considering the results of the study.