Recent advances in the development of cyclin-dependent kinase 7 inhibitors
Abstract
Cyclin dependent kinase 7 (CDK7) plays a double role as it activates several other cyclin dependent kinases and participates to the initiation of transcription. This kinase is overexpressed in various types of tumors. Relatively few selective CDK7 inhibitors have been up to now disclosed. Most of th …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
cell line
cell survival / drug effects
protein kinase inhibitors / pharmacology
pmid:31514062
doi:10.1016/j.ejmech.2019.111641
yuou teng
kui lu
nassima oumata
antineoplastic agents / chemistry*
antineoplastic agents / pharmacology
cyclin-dependent kinases / antagonists & inhibitors*
drug development
protein kinase inhibitors / chemistry*
pyrimidines / chemistry*
pyrimidines / pharmacology
triazines / chemistry*
triazines / pharmacology
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