The PI3K Pathway in Human Disease
Abstract
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K pathway-targeted therapies have been tested in oncology trials, resulting in regulatory approval of one isoform-selectiv …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
signal transduction*
neoplasms / drug therapy
neoplasms / pathology
neoplasms / metabolism
pmid:28802037
pmc5726441
doi:10.1016/j.cell.2017.07.029
david a fruman
honyin chiu
robert t abraham
cell physiological phenomena
immune system / metabolism
phosphatidylinositol 3-kinases / metabolism*
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119730
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