Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion

Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion

Lambert DM;Barney S;Lambert AL;Guthrie K;Medinas R;Davis DE;Bucy T;Erickson J;Merutka G;Petteway SR;;
Proceedings of the National Academy of Sciences of the United States of America 1996 Vol. 93 pp. -
328
dm1996proceedingspeptides

Abstract

The synthetic peptides DP-107 and DP-178 (T-20), derived from separate domains within the human immunodeficiency virus type 1 (HIV-1) transmembrane (TM) protein, gp4l, are stable and potent inhibitors of HIV-1 infection and fusion. Using a computer searching strategy (computerized antiviral searchin …

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